Article
Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis.
The Journal of cell biology - 22 Mar 2010
Yang Jingxuan, Meyer Michael, Müller Anna-Katharina, Böhm Friederike, Grose Richard, Dauwalder Tina, Verrey Francois, Kopf Manfred, Partanen Juha, Bloch Wilhelm, Ornitz David M, Werner Sabine
Abstract excerpt
Fibroblast growth factors (FGFs) are master regulators of organogenesis and tissue homeostasis. In this study, we used different combinations of FGF receptor (FGFR)-deficient mice to unravel their functions in the skin. Loss of the IIIb splice variants of FGFR1 and FGFR2 in keratinocytes caused progressive loss of skin appendages, cutaneous inflammation, keratinocyte hyperproliferation, and acanthosis. We...
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