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Article

FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review).

International journal of molecular medicine - 1 Mar 2009

Katoh Yuriko, Katoh Masaru

Abstract excerpt

FGFR2 gene at human chromosome 10q26 encodes FGFR2b and FGFR2c isoforms functioning as FGF receptors with distinct expression domain and ligand specificity. FGFR2 plays oncogenic and anti-oncogenic roles in a context-dependent manner. Single nucleotide polymorphisms (SNPs) within intron 2 of FGFR2 gene are associated with breast cancer through allelic FGFR2 upregulation. Missense mutations or copy number gains of...

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Source

Identifiers

PMID: 19212647
DOI: 10.3892/ijmm_00000132

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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