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Temporal variation in p38-mediated regulation of DUX4 in facioscapulohumeral muscular dystrophy

2 Nov 2024

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is a degenerative muscle disease caused by loss of epigenetic silencing and ectopic reactivation of the embryonic double homeobox protein 4 gene (DUX4) in skeletal muscle. The p38 MAP kinase inhibitor losmapimod is currently being tested in FSHD clinical trials due to the finding that p38 inhibition suppresses DUX4 expression in preclinical models. However, the role...

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PMID: 39488616
DOI: 10.1038/s41598-024-77911-8

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