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Article

Pharmacological monitoring of azathioprine therapy.

Scandinavian journal of gastroenterology - 1 Sept 2003

Reuther L O, Sonne J, Larsen N E, Larsen B, Christensen S, Rasmussen S N, Tofteng F, Haaber A, Johansen N, Kjeldsen J, Schmiegelow K

Abstract excerpt

BACKGROUND: Studies on azathioprine (Aza) treatment in Crohn disease have indicated a positive correlation between clinical remission and a concentration in erythrocytes of the metabolites 6-thioguanine nucleotides (E-6-TGN) above 230 pmol/8 x 10(8) RBC. A concentration of the methylated Aza metabolites (E-6-MMP) above 5000 pmol/8 x 10(8) RBC has been correlated to hepatotoxicity. Thiopurine methyltransferase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14531535
DOI: 10.1080/00365520310005082

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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