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Article

Clinical use and practical application of TPMT enzyme and 6-mercaptopurine metabolite monitoring in IBD.

Reviews in gastroenterological disorders - 1 Jan 2003

Seidman Ernest G

Abstract excerpt

6-mercaptopurine (6-MP) and its parent drug azathioprine (AZA) have been proven to be effective for both steroid-dependent and chronically active, or steroid-resistant inflammatory bowel disease, as well as for the prevention of relapse. Concerns about toxicity, delayed onset of action, and therapeutic failure (1 out of 3 patients) have restricted their use. Recent pharmacogenetic advances have led to the...

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Source

Identifiers

PMID: 12684587

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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