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Potential Role of NRF2 Agonist in Managing AHR-Mediated Chloracne by Dioxin

2018-06-13

Abstract excerpt

Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-erythroid 2-related factor-2 (NRF2) is a master switch inducing expression of various antioxidative enzymes such as heme oxyge...

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Literature Corpus work
8d2a5eef-eb26-59f1-911e-bd62e190ea27
DOI
10.20944/preprints201806.0205.v1
Open publication

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