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Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo.

Toxicology - 15 Aug 2017

Loboda Agnieszka, Stachurska Anna, Sobczak Mateusz, Podkalicka Paulina, Mucha Olga, Jozkowicz Alicja, Dulak Jozef

Abstract excerpt

Several mechanisms are postulated to be responsible for nephrotoxic and nephrocarcinogenic activities of mycotoxin and food contaminant, ochratoxin A (OTA). Although Nrf2 transcription factor was suggested to be involved in OTA-mediated renal injury, comprehensive study evaluating the effect of OTA toxicity in Nrf2 knock-out mice with special regard to sex-dependency has not been performed yet. Our results...

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PMID: 28710020
DOI: 10.1016/j.tox.2017.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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