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Article

Accessory mutations maintain stability in drug-resistant HIV-1 protease.

Journal of molecular biology - 22 Jul 2011

Chang Max W, Torbett Bruce E

Abstract excerpt

The underlying mechanisms driving the evolution of drug resistance in human immunodeficiency virus (HIV) are only partially understood. We investigated the evolutionary cost of the major resistance mutations in HIV-1 protease in terms of protein stability. The accumulation of resistance mutations destabilizes the protease, limiting further adaptation. From an analysis of clinical isolates, we identified specific...

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Share to Calorimetry, Differential Scanning
Share to Drug Resistance, Viral
Share to Enzyme Stability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HIV Protease Inhibitors

Share to Hydrogen-Ion Concentration

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Share to Protein Multimerization

Source

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Identifiers

PMID: 21762813
DOI: 10.1016/j.jmb.2011.03.038
PMCID: PMC3139113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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