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Article

Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment.

Tropical medicine & international health : TM & IH - 1 Feb 2007

Mugittu Kefas, Priotto Gerardo, Guthmann Jean-Paul, Kiguli James, Adjuik Martin, Snounou Georges, Beck Hans-Peter, Mshinda Hassan, Olliaro Piero L, Taylor Walter R J

Abstract excerpt

Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115) or three (n = 117) days artesunate (1AS, 3AS 4 mg/kg/day) plus sulphadoxine-pyrimethamine (SP) vs. SP alone (n = 153) was conducted in Mbarara, a mesoendemic area of western Uganda. All paired recurrent Plasmodium falciparum...

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PMID: 17300628
DOI: 10.1111/j.1365-3156.2007.01813.x

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