Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.

PLoS medicine - 1 Jul 2005

Yeka Adoke, Banek Kristin, Bakyaita Nathan, Staedke Sarah G, Kamya Moses R, Talisuna Ambrose, Kironde Fred, Nsobya Samuel L, Kilian Albert, Slater Madeline, Reingold Arthur, Rosenthal Philip J, Wabwire-Mangen Fred, Dorsey Grant

Abstract excerpt

BACKGROUND: Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of resistance, but artemisinins are expensive and relatively untested in highl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amodiaquine
Share to Artemisinins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chloroquine

Share to Infections

Share to Pyrimethamine

Share to Sesquiterpenes

Share to Sulfadoxine

Share to Uganda

Source

Open in PubMed Open full text

Identifiers

PMID: 16033307
DOI: 10.1371/journal.pmed.0020190
PMCID: PMC1181876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16033307-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.PMID 16033307Read ↗

Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria.Semantic proximity Read ↗

Artesunate + amodiaquine and artesunate + sulphadoxine–pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine‐resistant haplotypesSemantic proximity Read ↗

Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy.Semantic proximity Read ↗

Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment.Semantic proximity Read ↗

Efficacy and Safety of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for The Treatment of Uncomplicated Plasmodium Falciparum Malaria and Prevalence of Molecular Markers Associated With Artemisinin and Partner Drug Resistance in UgandaSemantic proximity Read ↗

Preventing antimalarial drug resistance with triple artemisinin-based combination therapiesSemantic proximity Read ↗

Slowing the spread of treatment failure to artemisinin-based combination therapies in UgandaSemantic proximity Read ↗

Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium falciparum multidrug resistance gene-1 polymorphisms in the Democratic Republic of Congo and Uganda.Semantic proximity Read ↗

Efficacy of fixed-dose combination artesunate-amodiaquine versus artemether-lumefantrine for uncomplicated childhood Plasmodium falciparum malaria in Democratic Republic of Congo: a randomized non-inferiority trial.Semantic proximity Read ↗

Recurrent Plasmodium falciparum Parasitemia and Drug Resistance Mutations During Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda.Semantic proximity Read ↗

Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of Plasmodium falciparum malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness.Semantic proximity Read ↗

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.