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Recurrent Plasmodium falciparum Parasitemia and Drug Resistance Mutations During Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda.

The Journal of infectious diseases - 16 Jun 2026

Kizza Jimmy, Katairo Thomas, Kakuru Abel, Nsengimaana Bienvenu, Esilu Trevor, Wiringilimaana Innocent, Semakuba Francis D, Gerlovina Inna, Hathaway Nicholas, Briggs Jessica, Tukwasibwe Stephen, Kiwuwa Steven M, Kamya Moses R, Nankabirwa Joaniter I, Dorsey Grant, Rosenthal Philip J

Abstract excerpt

BACKGROUND: Intermittent preventive treatment with monthly sulfadoxine-pyrimethamine (IPTp-SP) is recommended during pregnancy in malaria-endemic countries. However, widespread resistance of Plasmodium falciparum to SP has compromised its efficacy, and the alternative dihydroartemisinin-piperaquine (DP) is under study. Potential selection of drug resistance is important. METHODS: We sequenced 1377 samples...

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Artemisinins
Dihydropteroate Synthase
Parasitemia
Pregnancy Complications, Parasitic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tetrahydrofolate Dehydrogenase

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PMID: 41679334
DOI: 10.1093/infdis/jiag074
PMCID: PMC13271411

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