Article
Plasmodium falciparum genotyping by microsatellites as a method to distinguish between recrudescent and new infections.
The American journal of tropical medicine and hygiene - 1 Jul 2005
Nyachieo Atunga, VAN Overmeir Chantal, Laurent Thierry, Dujardin Jean-Claude, D'Alessandro Umberto
Abstract excerpt
In vivo tests for susceptibility to antimalarial drugs require molecular methods to distinguish recrudescence from new infection. The most commonly used DNA markers (merozoite surface proteins [MSPs]) are under immune selective pressure, which might lead to misclassification. We evaluated immunologically neutral microsatellite markers in blood samples collected during a drug efficacy trial in Rwanda. Fifty...
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