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Article

Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase.

The Journal of biological chemistry - 27 Apr 2001

Pike B L, Hammet A, Heierhorst J

Abstract excerpt

Forkhead-associated (FHA) domains are multifunctional phosphopeptide-binding modules and are the hallmark of the conserved family of Rad53-like checkpoint protein kinases. Rad53-like kinases, including the human tumor suppressor protein Chk2, play crucial roles in cell cycle arrest and activation of repair processes following DNA damage and replication blocks. Here we show that ectopic expression of the...

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Identifiers

PMID: 11278522
DOI: 10.1074/jbc.M009558200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase.PMID 11278522Read ↗

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