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Article

The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2022

Cario Alisa, Savastano Adriana, Wood Neil B, Liu Zhu, Previs Michael J, Hendricks Adam G, Zweckstetter Markus, Berger Christopher L

Abstract excerpt

The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein motility, and participate in signaling cascades. Tau misregulation and point mutations are linked to neurodegenerative diseases, including progressive supranuclear palsy (PSP), Pick's disease, and Alzheimer's disease....

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Identifiers

PMID: 35135879
DOI: 10.1073/pnas.2114215119
PMCID: PMC8851524

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The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure.PMID 35135879Read ↗

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