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Article

p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis.

The Journal of biological chemistry - 13 Apr 2007

Gal Jozsef, Ström Anna-Lena, Kilty Renee, Zhang Fujian, Zhu Haining

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurode-generative disease characterized by motor neuron death. A hallmark of the disease is the appearance of protein aggregates in the affected motor neurons. We have found that p62, a protein implicated in protein aggregate formation, accumulated progressively in the G93A mouse spinal cord. The accumulation of p62 was in parallel to the increase of...

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Source

Identifiers

PMID: 17296612
DOI: 10.1074/jbc.M608787200

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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