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Article

Non-homologous end-joining for repairing I-SceI-induced DNA double strand breaks in human cells.

DNA repair - 1 Jun 2007

Honma Masamitsu, Sakuraba Mayumi, Koizumi Tomoko, Takashima Yoshio, Sakamoto Hiroko, Hayashi Makoto

Abstract excerpt

DNA double strand breaks (DSBs) are usually repaired through either non-homologous end-joining (NHEJ) or homologous recombination (HR). While HR is basically error-free repair, NHEJ is a mutagenic pathway that leads to deletion. NHEJ must be precisely regulated to maintain genomic integrity. To clarify the role of NHEJ, we investigated the genetic consequences of NHEJ repair of DSBs in human cells. Human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17296333
DOI: 10.1016/j.dnarep.2007.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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