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Article

The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon.

Molecular and cellular biology - 1 Jan 1992

Yoon H J, Donahue T F

Abstract excerpt

We initiated a genetic reversion analysis at the HIS4 locus to identify components of the translation initiation complex that are important for ribosomal recognition of an initiator codon. Three unlinked suppressor loci, suil, sui2, and SUI3, that restore expression of both HIS4 and HIS4-lacZ in the absence of an AUG initiator codon were identified. In previous studies, it was demonstrated that the sui2 and SUI3...

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Identifiers

PMID: 1729602
DOI: 10.1128/mcb.12.1.248-260.1992
PMCID: PMC364089

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The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon.PMID 1729602Read ↗

Genetic characterization of the Saccharomyces cerevisiae translational initiation suppressors sui1, sui2 and SUI3 and their effects on HIS4 expression.Semantic proximity Read ↗

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon.Semantic proximity Read ↗

The Mof2/Sui1 protein is a general monitor of translational accuracy.Semantic proximity Read ↗

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.Semantic proximity Read ↗

SSL1, a suppressor of a HIS4 5'-UTR stem-loop mutation, is essential for translation initiation and affects UV resistance in yeast.Semantic proximity Read ↗

The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.Semantic proximity Read ↗

Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiation.Semantic proximity Read ↗

Loss of a conserved tRNA anticodon modification perturbs cellular signaling.Semantic proximity Read ↗

tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic selection for mistranslation rescues a defective co-chaperone in yeast.Semantic proximity Read ↗

Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome.Semantic proximity Read ↗

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