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Article

Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head.

Experimental & molecular medicine - 31 May 2010

Hong Jung Min, Kim Tae Ho, Kim Hyun Ju, Park Eui Kyun, Yang Eun Kyoung, Kim Shin Yoon

Abstract excerpt

Multiple factors have been implicated in the development of osteonecrosis of the femoral head (ONFH). In particular, non-traumatic ONFH is directly or indirectly related to injury of the vascular supply to the femoral head. Thus, hypoxia in the femoral head caused by impaired blood flow may be an important risk factor for ONFH. In this study, we investigated whether genetic variations of angiogenesis- and...

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Source

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Identifiers

PMID: 20215856
DOI: 10.3858/emm.2010.42.5.039
PMCID: PMC2877256

Genes

ACE
IGFBP3
KDR
NRP1
VEGFC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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