Article
Promoter polymorphisms of the vascular endothelial growth factor gene is associated with an osteonecrosis of the femoral head in the Korean population.
Osteoarthritis and cartilage - 1 Mar 2008
Kim T -H, Hong J M, Lee J -Y, Oh B, Park E K, Lee C -K, Bae S -C, Kim S -Y
Abstract excerpt
OBJECTIVE: Disruption of the vascular supply to the bone and subsequent hypoxia has been implicated in the pathogenesis of osteonecrosis of the femoral head (ONFH). Vascular endothelial growth factor (VEGF), a major inducer of angiogenesis, has been correlated with several pathological conditions, from inflammation to ischemic processes. A number of polymorphisms in the VEGF gene have been described as being...
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