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Article

Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence.

Aging cell - 1 Apr 2007

Yang Dan, McCrann Donald J, Nguyen Hao, St Hilaire Cynthia, DePinho Ronald A, Jones Matthew R, Ravid Katya

Abstract excerpt

We previously reported that the frequency of polyploid aortic vascular smooth muscle cells (VSMC) serves as a biomarker of aging. Cellular senescence of somatic cells is another marker of aging that is characterized by the inability to undergo cell division. Here, we examined whether polyploidy is associated with the development of cellular senescence in vivo. Analysis of aortic tissue preparations from young and...

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Identifiers

PMID: 17291294
DOI: 10.1111/j.1474-9726.2007.00274.x
PMCID: PMC3303600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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