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Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

30 Jan 2007

Abstract excerpt

It has been hypothesized that a replication associated repair pathway operates on base damage and single strand breaks (SSB) at replication forks. In this study, we present the isolation from the nuclei of human cycling cells of a multiprotein complex containing most of the essential components of base excision repair (BER)/SSBR, including APE1, UNG2, XRCC1 and POLbeta, DNA PK, replicative POLalpha, delta and...

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PMID: 17289756
DOI: 10.1093/nar/gkl1159

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