Article
Reduced midbrain serotonin transporter availability in drug-naïve patients with depression measured by SERT-specific [(123)I] nor-beta-CIT SPECT imaging.
Psychiatry research - 28 Feb 2007
Joensuu Mikko, Tolmunen Tommi, Saarinen Pirjo I, Tiihonen Jari, Kuikka Jyrki, Ahola Pasi, Vanninen Ritva, Lehtonen Johannes
Abstract excerpt
Earlier results have indicated that serotonin transporter (SERT) availability is altered in major depression. We examined SERT density with a more serotonin-specific ligand and with a larger number of patients than in previous studies. Twenty-nine antidepressant-naïve patients with major depressive disorder (MDD) and 19 healthy age- and sex-matched controls were studied with SPECT using [(123)I] nor-beta-CIT as a...
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