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Article

Effects of Selective Serotonin Reuptake Inhibitors on Interregional Relation of Serotonin Transporter Availability in Major Depression

6 Feb 2017

Abstract excerpt

Selective serotonin reuptake inhibitors (SSRIs) modulate serotonergic neurotransmission by blocking reuptake of serotonin from the extracellular space. Up to now, it has been unclear how SSRIs achieve their antidepressant effect. However, task-based and resting state functional MRI studies, have demonstrated connectivity changes between brain regions. Here, we use positron emission tomography (PET) to quantify...

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PMID: 28220069
DOI: 10.3389/fnhum.2017.00048

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