Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.

doi:10.1016/j.tins.2006.02.006

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Article

Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.

Trends in neurosciences - 1 Apr 2006

Vitaterna Martha Hotz, Pinto Lawrence H, Takahashi Joseph S

Abstract excerpt

Significant developments have occurred in our understanding of the mammalian genome thanks to informatics, expression profiling and sequencing of the human and rodent genomes. However, although these facets of genomic analysis are being addressed, analysis of in vivo gene function remains a formidable task. Evaluation of the phenotype of mutants provides powerful access to gene function, and this approach is...

Topics

Animals
Behavior, Animal
Chromosome Mapping
Genetics, Behavioral
Genomics
Interinstitutional Relations
Mice
Mice, Mutant Strains
Mutagenesis
National Institutes of Health (U.S.)
Phenotype
Quantitative Trait Loci
Research Design
United States

Source

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Identifiers

PMID: 16519954
DOI: 10.1016/j.tins.2006.02.006
PMCID: PMC3761413

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