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Article

Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.

Human genetics - 1 May 2007

Akagawa Hiroyuki, Narita Akira, Yamada Haruhiko, Tajima Atsushi, Krischek Boris, Kasuya Hidetoshi, Hori Tomokatsu, Kubota Motoo, Saeki Naokatsu, Hata Akira, Mizutani Tohru, Inoue Ituro

Abstract excerpt

Four lysyl oxidase family genes (LOXL1, LOXL2, LOXL3, and LOXL4), which catalyze cross-linking of collagen and elastin, were considered to be functional candidates for intracranial aneurysms (IA) and were extensively screened for genetic susceptibility in Japanese IA patients. Total RNA was isolated from four paired ruptured IA and superficial temporal artery (STA) tissue and examined by real-time RT-PCR. The...

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Source

Identifiers

PMID: 17287949
DOI: 10.1007/s00439-007-0333-3

Genes

LOXL2
LOXL1
ELN
LIMK1
LOXL3
LOXL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.PMID 17287949Read ↗

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