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Article

Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population.

Journal of human genetics - 1 Mar 2011

Low Siew-Kee, Zembutsu Hitoshi, Takahashi Atsushi, Kamatani Naoyuki, Cha Pei-Chieng, Hosono Naoya, Kubo Michiaki, Matsuda Koichi, Nakamura Yusuke

Abstract excerpt

Genetic factors are known to have an important role in intracranial aneurysm (IA) pathogenesis. The purpose of this study is to identify single-nucleotide polymorphisms (SNPs) that are associated with IA in Japanese population. A total of 2050 IA patients and 1835 controls recruited in Biobank Japan, The University of Tokyo were used in this study. In all, 45 SNPs in 24 genes encoding proteins, which have been...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Asian People
Case-Control Studies
Female
Humans
Intracranial Aneurysm
Lim Kinases
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matrix Metalloproteinase 2

Middle Aged

Polymorphism, Single Nucleotide

Sex Factors

Tumor Necrosis Factor-alpha

Young Adult

Source

Identifiers

PMID: 21228795
DOI: 10.1038/jhg.2010.169

Genes

LIMK1
MMP2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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