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Article

HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints.

The Journal of rheumatology - 1 Apr 2006

Carroll Graeme J

Abstract excerpt

OBJECTIVE: . To test the hypothesis that possession of either C282Y or H63D mutations in the HFE gene is associated with primary osteoarthritis (OA) in joints commonly affected in hemochromatotic arthropathy. METHODS: HFE genotyping was performed in 87 patients with radiologically proven OA in 3 joint regions: index or middle finger metacarpophalangeal joints (MCP2,3; n = 52), elbow joints (n = 8), ankle,...

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Source

Identifiers

PMID: 16583477

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints.PMID 16583477Read ↗

Primary osteoarthritis in the ankle joint is associated with finger metacarpophalangeal osteoarthritis and the H63D mutation in the HFE gene: evidence for a hemochromatosis-like polyarticular osteoarthritis phenotype.Semantic proximity Read ↗

Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D).Semantic proximity Read ↗

Association of heterozygous hemochromatosis C282Y gene mutation with hand osteoarthritis.Semantic proximity Read ↗

Polyarticular osteoarthritis--two major phenotypes hypothesized.Semantic proximity Read ↗

The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis.Semantic proximity Read ↗

HFE mutations in an inflammatory arthritis population.Semantic proximity Read ↗

HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis.Semantic proximity Read ↗

Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study.Semantic proximity Read ↗

Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis.Semantic proximity Read ↗

Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.Semantic proximity Read ↗

Confirmation of two major polyarticular osteoarthritis (POA) phenotypes--differentiation on the basis of joint topography.Semantic proximity Read ↗

Arthritis in hemochromatosis or iron storage disease.Semantic proximity Read ↗

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