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Article

The Relationship Between GSTT1, GSTM1, GSTO1, GSTP1 and MTHFR Gene Polymorphisms and DNA Damage of BRCA1 and BRCA2 Genes in Arsenic-Exposed Workers.

Journal of occupational and environmental medicine - 1 Apr 2021

Qian Shuran, Tan Jingwen, Zhou Qian, Yin Jinyao, Li Hui, He Yuefeng

Abstract excerpt

OBJECTIVE: To investigate the associations between genetic polymorphisms of GSTT1, GSTM1, GSTO1, GSTP1 and MTHFR genes and the DNA damage levels of BRCA1 and BRCA2 genes. METHODS: Peripheral blood samples were used to measure DNA damage levels and genetic polymorphisms, and urine samples were collected to analyze arsenic metabolites in 79 arsenic-exposed workers and 24 non-arsenic-exposed workers. RESULTS: The...

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PMID: 33443393
DOI: 10.1097/JOM.0000000000002142

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