Article
Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption.
Molecular and cellular biology - 1 Apr 2007
Chu Jessica Y S, Chung Samuel C K, Lam Amy K M, Tam Sidney, Chung Sookja K, Chow Billy K C
Abstract excerpt
Aquaporin 2 (AQP2) is responsible for regulating the concentration of urine in the collecting tubules of the kidney under the control of vasopressin (Vp). Studies using Vp-deficient Brattleboro rats, however, indicated the existence of substantial Vp-independent mechanisms for membrane insertion, as well as transcriptional regulation, of this water channel. The Vp-independent mechanism(s) is clinically relevant...
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