Article
Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene.
The Journal of clinical investigation - 1 Dec 2000
Yun J, Schöneberg T, Liu J, Schulz A, Ecelbarger C A, Promeneur D, Nielsen S, Sheng H, Grinberg A, Deng C, Wess J
Abstract excerpt
The V2 vasopressin receptor (V2R) plays a key role in the maintenance of a normal body water balance. To generate an in vivo model that allows the physiological and molecular analysis of the role of V2Rs in kidney function, we have created mouse lines that lack functional V2Rs by using targeted mutagenesis in mouse embryonic stem cells. Specifically, we introduced a nonsense mutation known to cause X-linked...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.