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Article

Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2.

American journal of physiology. Renal physiology - 1 May 2007

Shi Peijun P, Cao Xiao R, Qu Jing, Volk Ken A, Kirby Patricia, Williamson Roger A, Stokes John B, Yang Baoli

Abstract excerpt

In mammals, the hormonal regulation of water homeostasis is mediated by the aquaporin-2 water channel (Aqp2) of the collecting duct (CD). Vasopressin induces redistribution of Aqp2 from intracellular vesicles to the apical membrane of CD principal cells, accompanied by increased water permeability. Mutations of AQP2 gene in humans cause both recessive and dominant nephrogenic diabetes insipidus (NDI), a disease...

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Source

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Identifiers

PMID: 17229678
DOI: 10.1152/ajprenal.00308.2006
PMCID: PMC2818797

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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