Article
Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus.
American journal of physiology. Renal physiology - 1 Aug 2006
Robben Joris H, Knoers Nine V A M, Deen Peter M T
Abstract excerpt
In the renal collecting duct, water reabsorption is regulated by the antidiuretic hormone vasopressin (AVP). Binding of this hormone to the vasopressin V2 receptor (V2R) leads to insertion of aquaporin-2 (AQP2) water channels in the apical membrane, thereby allowing water reabsorption from the pro-urine to the interstitium. The disorder nephrogenic diabetes insipidus (NDI) is characterized by the kidney's...
Topics
- Amino Acid Sequence
- Aquaporin 2
- DNA
- Diabetes Insipidus, Nephrogenic
- Gene Expression Regulation
- Genetic Diseases, X-Linked
- Humans
- Molecular Sequence Data
- Mutation
- Receptors, Vasopressin