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Article

PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample.

Neurology - 27 Jan 2004

Bertram L, Menon R, Mullin K, Parkinson M, Bradley M L, Blacker D, Tanzi R E

Abstract excerpt

PEN2 is a reasonable Alzheimer's disease (AD) candidate gene because it is a necessary component of the gamma-secretase complex that generates beta-amyloid peptide. Moreover, its gene (PEN2) maps to a highly significant linkage region on chromosome 19q13. Four common polymorphisms in PEN2 were tested for genetic association with AD in a large and carefully ascertained AD family sample (789 subjects from 202...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14745076
DOI: 10.1212/01.wnl.0000103283.65914.0b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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