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Article

Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.

Journal of neurochemistry - 1 Apr 2006

Hansson Camilla A, Popescu Bogdan O, Laudon Hanna, Cedazo-Minguez Angel, Popescu Laurentiu M, Winblad Bengt, Ankarcrona Maria

Abstract excerpt

gamma-Secretase is a key enzyme involved in the processing of the beta-amyloid precursor protein into amyloid beta-peptides (Abeta). Abeta accumulates and forms plaques in Alzheimer's disease (AD) brains. A progressive neurodegeneration and cognitive decline occurs during the course of the disease, and Abeta is believed to be central for the molecular pathogenesis of AD. Apoptosis has been implicated as one of...

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Identifiers

PMID: 16539675
DOI: 10.1111/j.1471-4159.2006.03735.x

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STS
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.PMID 16539675Read ↗

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