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Article

Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.

Journal of neurochemistry - 1 Apr 2006

Hansson Camilla A, Popescu Bogdan O, Laudon Hanna, Cedazo-Minguez Angel, Popescu Laurentiu M, Winblad Bengt, Ankarcrona Maria

Abstract excerpt

gamma-Secretase is a key enzyme involved in the processing of the beta-amyloid precursor protein into amyloid beta-peptides (Abeta). Abeta accumulates and forms plaques in Alzheimer's disease (AD) brains. A progressive neurodegeneration and cognitive decline occurs during the course of the diseas...

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Identifiers

PMID: 16539675
DOI: 10.1111/j.1471-4159.2006.03735.x

Genes

STS
APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16539675-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.PMID 16539675Read ↗

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