Article
Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells.
Journal of virology - 1 Dec 2001
Lai L, Liu H, Wu X, Kappes J C
Abstract excerpt
Mutations in the IN domain of retroviral DNA may affect multiple steps of the virus life cycle, suggesting that the IN protein may have other functions in addition to its integration function. We previously reported that the human immunodeficiency virus type 1 IN protein is required for efficient viral DNA synthesis and that this function requires specific interaction with other viral components but not enzyme...
Topics
- Base Sequence
- Cell Line
- DNA Primers
- DNA Replication
- DNA, Viral
- Humans
- Integrases
- Moloney murine leukemia virus
- Mutation
- Virion