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Article

SOCS3 gene silencing does not occur through methylation and mutations in gastric cancer.

Human cell - 1 Jul 2022

Al Saqri Atika, Malgundkar Shika Hanif, Al Kindi Fatima, Gupta Ishita, Al Moundhri Mansour, Tamimi Yahya

Abstract excerpt

Gastric cancer (GC) is ranked the third leading cause of cancer-related deaths worldwide. Mutations and epigenetic alterations in several essential genes, including p53, KRAS, PIK3CA, FAT4 and ARID1A, are often reported. Furthermore, loss of SOCS3 expression was reported in GC, suggesting its tumor suppressor role. To assess the mutational and methylation status of SOCS3, we performed gene panel exome sequencing...

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Share to Cell Line, Tumor
Share to DNA Methylation
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Long Noncoding

Share to Stomach Neoplasms

Share to Suppressor of Cytokine Signaling 3 Protein

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Identifiers

PMID: 35596898
DOI: 10.1007/s13577-022-00715-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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