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Article

Gene methylation and silencing of <i><scp>SOCS</scp>3</i> in mantle cell lymphoma

22 Feb 2013

Abstract excerpt

The significance of loss of SOCS3, a negative regulator of signalling pathways including those of STAT3 and NF-κB, was examined in mantle cell lymphoma (MCL). The protein expression and gene methylation status of SOCS3 were detected using immunohistochemistry/Western blots and methylation-specific polymerase chain reaction, respectively. To evaluate its functional importance, SOCS3 was restored in two...

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PMID: 23432547
DOI: 10.1111/bjh.12262

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