Article
Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3.
Genomics - 15 Sept 1994
Rothnagel J A, Longley M A, Bundman D S, Naylor S L, Lalley P A, Jenkins N A, Gilbert D J, Copeland N G, Roop D R
Abstract excerpt
Loricrin is the major component of a specialized structure, termed the cornified cell envelope, that is formed beneath the plasma membrane of stratified squamous epithelial cells and is coexpressed with profilaggrin in terminally differentiating epidermal keratinocytes. Full-length cDNAs for both mouse and human loricrin have been cloned and characterized, as has the human gene. Here we report the isolation and...
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