Article
Aging-associated vascular phenotype in mutant mice with low levels of BubR1.
Stroke - 1 Mar 2007
Matsumoto Takuya, Baker Darren J, d'Uscio Livius V, Mozammel Gazi, Katusic Zvonimir S, van Deursen Jan M
Abstract excerpt
BACKGROUND AND PURPOSE: Aging is a major risk for stroke and a highly complex biological process believed to involve multiple mechanisms. Mutant mice that express low levels of the spindle assembly checkpoint protein BubR1 are known to develop several aging-associated phenotypes at a very young age, including cataracts, lordokyphosis, loss of subcutaneous fat, and impaired wound healing. However, whether BubR1...
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