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Article

Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension.

American journal of physiology. Cell physiology - 1 May 2007

Remillard Carmelle V, Tigno Donna D, Platoshyn Oleksandr, Burg Elyssa D, Brevnova Elena E, Conger Diane, Nicholson Ann, Rana Brinda K, Channick Richard N, Rubin Lewis J, O'connor Daniel T, Yuan Jason X-J

Abstract excerpt

The pore-forming alpha-subunit, Kv1.5, forms functional voltage-gated K(+) (Kv) channels in human pulmonary artery smooth muscle cells (PASMC) and plays an important role in regulating membrane potential, vascular tone, and PASMC proliferation and apoptosis. Inhibited Kv channel expression and function have been implicated in PASMC from patients with idiopathic pulmonary arterial hypertension (IPAH). Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17267549
DOI: 10.1152/ajpcell.00405.2006

Genes

KCNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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