Article
Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.
Biochemical and biophysical research communications - 16 Mar 2007
Nielsen Nathalie H, Winkel Bo G, Kanters Jørgen K, Schmitt Nicole, Hofman-Bang Jacob, Jensen Henrik S, Bentzen Bo H, Sigurd Bjarne, Larsen Lars A, Andersen Paal S, Haunsø Stig, Kjeldsen Keld, Grunnet Morten, Christiansen Michael, Olesen Søren-Peter
Abstract excerpt
Mutations in one of the ion channels shaping the cardiac action potential can lead to action potential prolongation. However, only in a minority of cardiac arrest cases mutations in the known arrhythmia-related genes can be identified. In two patients with arrhythmia and cardiac arrest, we identified the point mutations P91L and E33V in the KCNA5 gene encoding the Kv1.5 potassium channel that has not previously...
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