Article
Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.
Advances in experimental medicine and biology - 1 Jan 1997
Langenbach R, Morham S G, Tiano H F, Loftin C D, Ghanayem B I, Chulada P C, Mahler J F, Davis B J, Lee C A
Abstract excerpt
Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at...
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