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Article

Cyclooxygenase Isoform Exchange Blocks Brain-Mediated Inflammatory Symptoms.

PloS one - 1 Jan 2016

Björk Wilhelms Daniel, Mirrasekhian Elahe, Zajdel Joanna, Kumar Singh Anand, Engblom David

Abstract excerpt

Cyclooxygenase-2 (COX-2) is the main source of inducible prostaglandin E2 production and mediates inflammatory symptoms including fever, loss of appetite and hyperalgesia. COX-1 is dispensable for fever, anorexia and hyperalgesia but is important for several other functions both under basal conditions and during inflammation. The differential functionality of the COX isoforms could be due to differences in the...

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Identifiers

PMID: 27861574
DOI: 10.1371/journal.pone.0166153
PMCID: PMC5115700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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