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Article

Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Morris Andrew P, Whittaker John C, Xu Chun-Fang, Hosking Louise K, Balding David J

Abstract excerpt

Single-nucleotide polymorphism (SNP) genotypes were recently examined in an 890-kb region flanking the human gene CYP2D6. Single-marker and haplotype-based analyses identified, with genomewide significance (P < 10-7), a 403-kb interval displaying strong linkage disequilibrium (LD) with predicted poor-metabolizer phenotype. However, the width of this interval makes the location of causal variants difficult: for...

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PMID: 14597696
DOI: 10.1073/pnas.2235031100
PMCID: PMC263833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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