Article
Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from central China.
Biochemical genetics - 1 Apr 2007
Zhang Shu-Lin, Qi Hua, Qiu Dun-Lian, Li Da-Xu, Zhang Jie, Du Chang-Mei, Wang Guo-Bin, Yang Zhi-Rong, Sun Qun
Abstract excerpt
DNA sequencing analysis was used to investigate genetic alterations in the rpoB, katG, and inhA regulatory region and embB in 66 Mycobacterium tuberculosis isolates recovered from Central China. Of the 36 multidrug-resistant isolates, 33 (92%) had mutations in the amplified region of rpoB. The most frequent mutation (58%, 19/36) was S531L (TCG-->TTG). At least one mutation was found in the katG and inhA...
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