Article
Genotyping and molecular characteristics of multidrug-resistant Mycobacterium tuberculosis isolates from China.
The Journal of infection - 1 Apr 2015
Zhang Zhijian, Lu Jie, Liu Min, Wang Yufeng, Qu Geping, Li Hongxia, Wang Jichun, Pang Yu, Liu Changting, Zhao Yanlin
Abstract excerpt
OBJECTIVES: The aim of this study was to explore the population structure of multidrug-resistant (MDR) tuberculosis strains and distribution of resistance-associated nucleotide alteration among the different genotype MDR strains in China. METHODS: The genotypes of 376 MDR strain were analyzed by 15-loci MIRU-VNTR and RD105 deletion-targeted multiplex PCR (DTM-PCR) method. In addition, all the MDR isolates were...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Catalase
- China
- DNA-Directed RNA Polymerases
- Drug Resistance, Multiple, Bacterial
- Genetic Variation
- Genotype
- Isoniazid
- Molecular Epidemiology