Article
Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.
Diagnostic microbiology and infectious disease - 1 Jun 2013
Jnawali Hum Nath, Hwang Sung Chul, Park Young Kil, Kim Hyejin, Lee Yeong Seon, Chung Gyung Tae, Choe Kang Hyeon, Ryoo Sungweon
Abstract excerpt
In order to characterize molecular mechanisms of first- and second-line drug resistance in Mycobacterium tuberculosis and to evaluate the use of molecular markers of resistance, we analyzed 62 multidrug-resistant, 100 extensively drug-resistant, and 30 pan-susceptible isolates from Korean tuberculosis patients. Twelve genome regions associated with drug resistance, including katG, ahpC, and inhA promoter for...
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