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Article

Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction

10 Dec 2019

Abstract excerpt

AIMS: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide linked to vascular diseases through a common intronic gene enhancer [(rs9349379-G allele), chromosome 6 (PHACTR1/EDN1)]. We performed a multimodality investigation into the role of ET-1 and this gene variant in the pathogenesis of coronary microvascular dysfunction (CMD) in patients with symptoms and/or signs of ischaemia but no obstructive coronary...

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PMID: 31972008
DOI: 10.1093/eurheartj/ehz915

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