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Article

Characterization of the proteasome interaction with the Sec61 channel in the endoplasmic reticulum.

Journal of cell science - 15 Feb 2007

Ng Waiyan, Sergeyenko Tatiana, Zeng Naiyan, Brown Jeremy D, Römisch Karin

Abstract excerpt

Biogenesis of secretory proteins requires their translocation into the endoplasmic reticulum (ER) through the Sec61 channel. Proteins that fail to fold are transported back into the cytosol and are degraded by proteasomes. For many substrates this retrograde transport is affected by mutations in...

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Source

Identifiers

PMID: 17264153
DOI: 10.1242/jcs.03351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17264153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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