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Article

Non-canonical role of wild-type SEC23B in the cellular stress response pathway.

Cell death & disease - 22 Mar 2021

Yehia Lamis, Liu Darren, Fu Shuai, Iyer Pranav, Eng Charis

Abstract excerpt

While germline recessive loss-of-function mutations in SEC23B in humans cause a rare form of anaemia, heterozygous change-of-function mutations result in increased predisposition to cancer. SEC23B encodes SEC23 homologue B, a component of coat protein complex II (COPII), which canonically transports proteins from the endoplasmic reticulum (ER) to the Golgi. Despite the association of SEC23B with anaemia and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33753724
DOI: 10.1038/s41419-021-03589-9
PMCID: PMC7985502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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